Near-haploid ALL cases showed alterations targeting genes in receptor tyrosine kinase (RTK) signaling and Ras signaling (NF1) pathways, as well as high frequency alterations in the IKAROS gene family, particularly IKZF3 (Aiolos) which encodes for the zinc finger transcription factor AIOLOS [22]. The gene discussed is IKZF3; the disease is acute lymphoblastic leukemia.