Targeted investigation of patient samples revealed approximately 7.5% of childhood B-ALL harbored mutations in WHSC1/NSD2 (particularly p.E1099K) but were enriched the B-ALL subtypes ETV-RUNX1 (20%) and TCF3-PBX1 (15%) [96]. Here, RUNX1 is linked to precursor B-cell acute lymphoblastic leukemia.