Gene sequencing studies in 2011 [106] and 2012 [107], demonstrated 20% of total pediatric ALL relapse cases [106] and 60% of high-hyperdiploid relapse cases [107] harbor mutations in CREBBP, a transcriptional co-activator and histone acetyltransferase (HAT). The gene discussed is CREBBP; the disease is acute lymphoblastic leukemia.