Transcriptome and whole-genome sequencing of BCR-ABL1–like ALL has also identified other genetic alterations involved in the activation of kinase signaling, including EBF1-PDGFRB, comprised of the transcription factor EBF1 (early B-cell factor 1) and the receptor tyrosine kinase PDGFRB (platelet-derived growth factor receptor β), resulting from 5q33q33 microdeletion [53,69]. This evidence concerns the gene NTRK1 and acute lymphoblastic leukemia.