Further analysis revealed that mutations in SETD2 were enriched in MLL-rearranged (22%) and the ETV-RUNX1 (13%) subtypes of B-ALL, and that over 50% of matched relapsed cases, regardless of subtype, demonstrated enrichment of mutations in epigenetic regulators (discussed more below) [97]. The gene discussed is KMT2A; the disease is acute lymphoblastic leukemia.