CASP3 and acute lymphoblastic leukemia: Recently, our group has provided evidence that oxidative stress (OS) generated by glucose-starvation (GS) induces apoptosis-inducing factor (AIF)- and caspase-3-dependent mitochondrial mechanisms of cell death in Jurkat cells (a model of human acute lymphoblastic leukemia) characterized by the activation of transcription factors such as nuclear factor-kappa B (NF-κB), p53, c-Jun; activation of c-Jun N-terminal kinase, AIF translocation to nuclei, mitochondria depolarization, and nuclear fragmentation as evidence of caspase-3 activation [18].