CD14, a highly specific receptor for lipopolysaccharides, is expressed on the surface of monocytes/macrophages.11 CD14 is found in two forms: membrane bound and soluble (sCD14).12 The normal range of the serum concentration of sCD14 in healthy adult volunteers was 1.5–5 mg/L.13 The serum concentration of sCD14 increased in sepsis and was associated with high mortality.14 To the best of our knowledge, the serum level of sCD14 in patients with DFUs has not been investigated before. This evidence concerns the gene CD14 and Sepsis.