Serum concentrations of β-hCG and PAPP-A were analyzed and CRL and NT were measured at the time of routine screening for Down’s Syndrome.The median values (range) of maternal serum β-hCG MoM and PAPP-A MoM in addition to CRL MoM and NT MoM in the study population are shown in Table-II. The gene discussed is PAPPA; the disease is Down syndrome.