P2RY12 and obesity due to melanocortin 4 receptor deficiency: It is known that diabetic patients have high platelet reactivity.11 Although insulin suppresses P2Y12 mediated platelet aggregation in healthy subjects,12 it is known that if there is insulin resistance such as DM accompanying central obesity, obesity and HT, there is unresponsiveness to the antiaggregant effect of insulin.12-14 In our study, patients who use insulin had significantly higher levels of HbA1c and hCRP levels, higher microalbuminuria, longer mean duration of DM and higher values of fasting glucose, post-prandial glucose.