Besides, rs12979860 polymorphism may also predict the spontaneous HCV clearance capacity of children during vertical transmission (especially the rs12979860 CC genotype children patients).10 Meanwhile, the polymorphism of IL-28B is closely associated with the development of CHC, and T/T genotype is more prevalent among cirrhosis patients.11 Therefore, understanding IL-28B gene polymorphism is important to predict the treatment therapy of interferon, as well as the spontaneous clearance capacity and histological changes of children patients. This evidence concerns the gene IFNL3 and Cirrhosis.