IFNL3 and cryohydrocytosis: Besides, rs12979860 polymorphism may also predict the spontaneous HCV clearance capacity of children during vertical transmission (especially the rs12979860 CC genotype children patients).10 Meanwhile, the polymorphism of IL-28B is closely associated with the development of CHC, and T/T genotype is more prevalent among cirrhosis patients.11 Therefore, understanding IL-28B gene polymorphism is important to predict the treatment therapy of interferon, as well as the spontaneous clearance capacity and histological changes of children patients.