The spontaneous clearance of HCV infection is low, and 50%-90% of acute hepatitis C patients eventually develop into CHC ones.12 IL-28B is a novel interleukin produced by a variety of cells (e.g. peripheral blood monocyte/dendritic cells, Hela cell) induced by viruses or double-stranded RNA. Here, IFNL3 is linked to cryohydrocytosis.