Different microtubule-associated protein tau (MAPT) gene mutations have been identified in many different tauopathies including AD, frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). The gene discussed is MAPT; the disease is Classical progressive supranuclear palsy.