TNFSF10 and cancer: This shortcoming has been addressed by the development of genetically engineered mouse models of various cancers, which closely resemble the full clinical spectra of the respective human cancers.138, 139 Hence, the challenge now is to determine whether newly devised high-activity TRAs combined with the most potent TRAIL-sensitizing strategies exert a therapeutic effect in these sophisticated mouse models of cancer to ultimately get TRAIL back on track to the cancer clinic.