Although colon and breast cancer cells primarily use TRAIL-R2 for apoptosis induction,101 lymphoid malignancies and pancreatic cancer cell lines have been reported to induce apoptosis primarily via TRAIL-R1.102, 103, 104 These differences in using one or the other receptor for apoptosis induction should be considered, when targeting cancer cells with TRAs specific for one of the two DD-containing TRAIL-R. Here, TNFRSF10A is linked to cancer.