For instance, the Hedgehog [38-40], Notch [41], and Nodal/Activin [26] pathways have been identified as having a role in the maintenance of pancreatic CSCs/CSLCs, for which pharmacological agents modulating their activities are already available for use and have shown therapeutic effects in preclinical models of pancreatic cancer. Here, INHBE is linked to familial pancreatic carcinoma.