Importantly, for as long as 6 months, no sustained tumor growth has taken place in any of the mice transplanted with tumor cells from SP600125-treated primary tumors (Figure 3A and B), which implies that the short-term, transient JNK inhibition was sufficient to deprive CSCs/CSLCs of their tumor-initiating capacity and at the same time prevent them from recovering it in vivo at least during the observation period. The gene discussed is MAPK8; the disease is neoplasm.