However, quite strikingly, the secondary tumors derived from the SP600125-treated primary tumors started to regress spontaneously ~ 4 weeks after transplantation (Figure 3A), suggesting that JNK inhibition in vivo limited, albeit did not abolish immediately, the self-renewal capacity of pancreatic CSCs/CSLCs to such a degree that they could no longer perpetuate tumor growth. Here, MAPK8 is linked to neoplasm.