The conformational change and auto-phosphorylation of the intracellular domain of HER2 can lead to downstream signaling via mitogen-activated protein kinase, phosphoinositide 3-kinase, phospholipase C, protein kinase C, and signal transducer and activator of transcription for mediating tumor growth, differentiation, and survival [9-13]. This evidence concerns the gene ERBB2 and neoplasm.