The Kaplan-Meier method was used to compare disease survival between FOXO3 high/RRM2B high (high/high) and FOXO3 low/RRM2B low (low/low) groups, and the results indicated that the high/high group exhibited significantly higher survival compared with that of the low/low group in these cancer patients (P = 0.0454) (Figure 5c). The gene discussed is FOXO3; the disease is cancer.