In addition, we noted that in pancreatic acinar cells, Amylase and CK19 mRNA levels were altered by PD2/Paf1 downregulation, which suggested that PD2/Paf1 may be involved in the maintenance of the terminally differentiated acinar cell population, and thus, act as an impediment to KrasG12D-driven acinar cell de-differentiation and tumor initiation. The gene discussed is PAF1; the disease is neoplasm.