As observed in subcutaneous implantations, JoMa1-ALK expressing cells rapidly induced tumor formation, and mice engrafted with JoMa1-ALK-F1174L cells developed tumors in AG much faster than JoMa1-ALK-R1275Q and JoMa1-ALK-wt bearing mice (p<0.02), while no tumor was found in mice implanted with JoMa1 or JoMa1-Migr control cells (Figure 3A). The gene discussed is ALK; the disease is neoplasm.