Furthermore, a previous study found that high PTOV1 expression might be a good predictor of prostate cancer in men with isolated high-grade prostatic intraepithelial neoplasms in needle biopsies [19,20].Thus, PTOV1 might be a positive regulator of breast cancer development and progression; however, the exact mechanism needs further investigation. The gene discussed is PTOV1; the disease is Familial prostate cancer.