PTOV1 and breast carcinoma: These findings suggested that overexpression of PTOV1 was an strong inverse prognostic factor for breast cancer patients in clinical stage I–II (early stage, P = 0.026) and III–IV (late stage, P = 0.001), indicating that PTOV1 could be considered as a valuable prognostic marker for breast cancer in all disease stages (Figure 4B, C).