FAS and gastrointestinal stromal tumor: Pharmaceutical molecules used to induce or promote apoptosis in GIST include Bortezomib, a dipeptide boronic acid inhibitor of the 20S proteasome that, in part, impedes the degradation of pro-apoptotic factors, thereby inducing apoptosis in neoplastic cells, and MegaFaL, a synthetic compound containing a hexameric form of soluble forms of Fas ligand (FasL; CD95L), which binds to Fas receptor for induction of Fas-mediated apoptosis[34,35].