Recent findings have demonstrated that B7-H1 (PD-L1), B7-H2 (PD-L2), B7-H3 and B7-H4 are aberrantly expressed in some tumor tissues and/or sera of cancer patients, suggesting that these molecules might be new molecular biomarkers for tumor diagnosis and prognosis[9-11]. The gene discussed is VTCN1; the disease is neoplasm.