Although a small number of markers have been reported for MF skin biopsies, including loss of CD13, ectopic expression of BLK gene, microRNAs (including miR-155, miR-203 and miR-205) [16-18], BCL7A loss [19, 20], enhanced AHI1 [21], and CD158K/KIR3DL2 in transformed advanced MF [22], few of these markers were tested in multicenter studies, or used in a clinical setting. Here, ANPEP is linked to mycosis fungoides.