In our study, we demonstrated that LH-induced autophagy downregulated the expression of the pro-apoptotic proteins Bad and Bim in the presence of chemotherapeutic agents in the HCC cells, while CQ or 3-MA or the RNAi of Atg5 or Atg7 can counteract this trend (Figure 5). Here, PLOD1 is linked to hepatocellular carcinoma.