Angiotensin II-subtype-1 (AT1) receptor blockers [5] or angiotensin-converting enzyme (ACE) inhibitors [6] slow the progression of CKD, yet they are contraindicated in bilateral renal artery stenosis or in unilateral renal artery stenosis and (functional) single kidney situation. This evidence concerns the gene AGTR1 and Renal artery stenosis.