The transcription factor SOX2 is involved together with c-MYC, KLF4 and OCT3/4 in the induction and maintenance of pluripotent stem cells and has been also associated the expression of both SOX2 and β-CATENIN with metastases and poor prognosis in colon cancer [15]. The gene discussed is MYC; the disease is malignant colon neoplasm.