We observed the down-regulation of genes involved in breast cancer tumorigenesis (BRCA1, DKK1, CLAUDIN1), tumor cell progression (NOTCH3, MAML2, VIMENTIN), multidrug resistance (VTRNA1-1), cell cycle progression (E2F8A), DNA reparation (BRCA1), metastasis (VIMENTIN, BRMS1L) and the up-regulation of genes involved in the inhibition of angiogenesis (CXCL10), apoptosis (CASP4), repressor of metastasis (BRMS1L) or genes involved in cell proliferation inhibition (CSE), among others (Fig. 3A). The gene discussed is NOTCH3; the disease is breast carcinoma.