Moreover, we also detected both the inhibition of ERKs and JNK phosphorylation in MCF-7 and MDA-MB 468 breast cancer cell lines, that was more notable in MCF-7 cells at 4 hours post-treatment and in MDA-MB 468 cell line after 8 hours post-treatment (Fig. 1B and 1C). Here, MAPK8 is linked to breast carcinoma.