Similar results were reported by Hughes et al. [9], who showed that only four loci (rs1270942 in the HLA, rs3131379 in MSH5 (HLA), rs10488631 in IRF5, and rs4963128 in KIAA1542) of the fifteen analyzed had significant differences between women and men with SLE. This evidence concerns the gene PHRF1 and systemic lupus erythematosus.