Not unexpectedly, given the aforementioned immune defects, with the exception of IL-1β at day 1 post-infection, no major increases in pro-inflammatory cytokine levels were detected in the sera of infected mice compared to control animals (Fig. S4); instead, we found that circulating levels of interferon (IFN)γ were reduced after 3 days of infection (Fig. S4). The gene discussed is IL1B; the disease is infection.