Interestingly, deletion of several genes encoding components of the chromatin and histone modification machinery (RPD3, HEK2, MPS3, SDS3, SIN3, ASF1) also modulated CF susceptibility, suggesting an important regulatory role for chromatin in controlling surface homeostasis and CF susceptibility, as recently demonstrated for the C. albicans Hat1 acetyltransferase [82]. Here, SUDS3 is linked to cystic fibrosis.