Since the fragmentation of HUVECs by infection with Bhe ΔbepDEF or ΔbepE mutant bacteria was associated with a distortion of rear edge detachment during cell migration, and because GFP-BepEBhe transiently localizes to this rear edge during detachment, we became interested in testing the role of the RhoA signaling pathway for BepE activity. The gene discussed is RHOA; the disease is infection.