For example, Nfatc2 KO mice are resistant to suppression of the G0 to G1 transition by nicotine [9], Nfatc2/Nfatc3-doubly deficient CD4+ Tconv cells are refractory to the effects of WT Treg cells in vitro [10], Nfatc2-deficient T cells resist tumor-induced anergy and promote tumor rejection [11], and mice with T cells harboring a hyperactivatable form of Nfatc2 show attenuated autoimmune responses to myelin basic protein [12]. This evidence concerns the gene CD4 and neoplasm.