Salivary glands from one of Nfatc2/Tob1 DKO mice examined microscopically showed lymphoid infiltration into the parenchyma, but this was no more severe than that observed in single Nfatc2 KO mice (Figure 7), suggesting Tob1 does not provide a compensatory mechanism to prevent or delay the lymphoid hyper-reactivity and tumor development observed under conditions of Nfatc2 deficiency. Here, TOB1 is linked to neoplasm.