TOB1 and experimental autoimmune encephalomyelitis: The only phenotype associated with Tob1 deficiency is increased bone mass [20]; this genotype does not produce gross immune defects, but T cells from Tob1 KO mice have a reduced threshold of activation in vitro and in vivo[4], [21], and in an experimental autoimmune encephalomyelitis model, Tob1 KO cells showed greater CNS inflammation with increased infiltrating CD4+ and CD8+ T cells, increased myelin-reactive Th1 and Th17 cells, and reduced numbers of Tregs [22].