This age-associated tumor phenotype was not seen in any of 12 age-matched WT (Nfatc2+/+, N = 6) or hemizygous (Nfatc2+/−N = 6) littermates, and unlike previous reports [18], no tumors developed in young or old Tob1 KO mice. Here, NFATC2 is linked to neoplasm.