However, the observation that oxazolone-induced ulcerative colitis and progression to colon cancer are attenuated in Nfatc2 KO mice due to ineffective production of IL-6 [13], [14] suggests that the function of Nfatc2 is not uniquely to repress cell cycle or lymphocyte activation, but rather, it can act as a more general modulator of inflammation and even as an oncogene in non-lymphoid cells. This evidence concerns the gene NFATC2 and ulcerative colitis.