ERBB2 and neoplasm: Epidermal growth factor receptor belongs to the ErbB family of tyrosine kinase receptors, which includes EGFR (ErbB-1), HER-2/neu (ErbB-2), HER-3 (ErbB-3), and HER-4 (ErbB-4), all known to be involved in modulating pathways of tumor growth or proliferation [11].