CDH1 and esophageal squamous cell carcinoma: This histological categorization was also associated with the EMT phenotype of ESCC (p = 0.002), which was defined in our previous study by immunohistochemical expression of mesenchymal marker and E-cadherin.[21] The complete EMT phenotype, characterized by loss of E-cadherin expression with acquirement of mesenchymal marker expression, was significantly more frequent in the immature CAF phenotypes than that in the other phenotypes.