Conversely, inhibition of gD protein expression in L929 cells expressing the FLAG-BAF-MAAAQ mutant is not merely the result of reducing viral DNA replication because HSV-1 gD is a prototype γ1 gene that is expressed early during infection and its expression is not dramatically altered by a viral inhibitor of DNA replication, phosphonoacetic acid for example [80]. This evidence concerns the gene PAEP and infection.