While BCG-GFP brought about a dramatic increase in the surface expression of CD40, CD54, CD80, CD86 and MHC-II (Figure 4A, blue line), infection of BMDC with BCG-TB1860 (Fig. 4A, green line) drastically reduced the expression of all five co-stimulatory molecules studied, to levels comparable to that found on uninfected DC (Fig. 4A, red line). The gene discussed is CD80; the disease is infection.