While these SCF ligase components were not reported to be significantly upregulated in a published dataset of the wild-type C. elegans response to viral infection [17], we found that in the virus-susceptible rde-1 strain of C. elegans, the SCF ligase components cul-6, skr-3, skr-4, and skr-5 were upregulated in response to viral infection (data not shown). This evidence concerns the gene TGFBR1 and viral infectious disease.