Collectively, while these data indicate 4E-BP1 phosphorylation and the interaction of eIF4E with eIF4G represent a regulatory control point under normal conditions (e.g., in WT mice), they also imply there must be at least one more additional control point distal to mRNA•eIF4E•eIF4G complex formation regulating the sepsis-induced decreases in muscle protein synthesis in the DKO mice. The gene discussed is EIF4E; the disease is Sepsis.