TNF and Sepsis: While some genotype effects were detected (i.e., larger increases in MuRF1, atrogin-1, IL-6 and TNFα in skeletal muscle of male DKO mice), there was no difference between WT and DKO animals in regards to their sepsis-induced decrease in body weight, acute 24-h survival, or the reduction in protein synthesis in muscle, heart or liver which might have been predicted given the exaggerated inflammatory cytokine response [8].