Collectively therefore these results indicate that the presence of viremia is likely to result in higher levels of cell death (following productive infection of the cell) and/or bystander apoptosis in G- CD4+T cells, resulting in the preferential depletion of this “unprotected" G- CD4+T cell subset and thereby driving the preferential expansion of the subset of G+ CD4+T cells. Here, CD4 is linked to infection.