Following intranasal infection with FITC labeled S. pneumoniae, we found a tendency for decreased phagocytosis by Ly6G+CD11b+ lung neutrophils from Trem-2−/− mice compared to their WT counterparts, suggesting that the modest increase in neutrophil numbers early during infection (Fig. 1G) was not responsible for the improved bacterial clearance of Trem-2−/− mice (Fig. 3K and L). The gene discussed is ITGAM; the disease is infection.