Collectively, the aforementioned observations appear to be in line with previous findings that suggest that RIN3 could influence osteoclast activity, especially when considering the prior association of RIN3 with Paget's Disease, a disease driven by osteoclast dysfunction and molecular studies that indicate that RIN3 is involved in vesicular trafficking, a process critical for bone resorption [20], [21]. This evidence concerns the gene RIN3 and Paget disease.