Furthermore, a recent study demonstrated that EMT is required for EGF-induced large gastric cancer (LGC) and ovarian cancer cell migration and invasion, and that EGF-induced EMT involves activation of the ERK1/2 and PI3K/AKT pathways with subsequent induction of Snail, Slug, and ZEB1 expression [18]. This evidence concerns the gene MAPK3 and gastric cancer.