BACE1 and infection: At the chronic stage of infection (24 weeks post challenge), older hepatic granulomas composed of concentric layers of macrophages, epithelioid cells, Langhans-type multinucleated giant cells and lymphocytes (Figures 6 and 8) were documented only in groups of control macaques (i.e., PBS, rhIL-12/alum, Ad5-ASP-2+rhIL-12/alum and DNA-wt/Ad5-ASP-2), thus revealing that parasite persisted until the end of the experiment.