PPARGC1A and myocardial ischemia: However, in contrast to patients with idiopathic dilated cardiomyopathy (DCM) and ischemic heart disease (IHD), patients with mitochondrial cardiomyopathy (MIC) have increased expression of genes involved in fatty acid metabolism, including Ucp2, Cpt1, Pparα and Pgc1-α[23].