The effects on the digestive system consisted of more frequent constipation (OR = 1.57), suggesting decreased gastrointestinal mobility probably due to dysfunctional autonomic activity (Winkler et al. 2011), associated with the accumulation of alpha-synuclein in the intestinal neurons (Lebouvier et al. 2009).The associations of PD with mental and behavioral disorders are well-known and represent other, nonmotor control areas of the brain affected by neurodegeneration. The gene discussed is SNCA; the disease is Parkinson disease.