Growth factors have diverse functions which overlap and contribute to immune responses but although elevated levels of growth factors including TGF-β, epidermal growth factor (EGF), and vascular endothelial growth factor (VEGF) have been reported in the GCF of patients with periodontitis [95], there is a dearth of information about salivary growth factors and periodontitis. The gene discussed is TGFB1; the disease is periodontitis.