In a Hopkins cohort study [19] of 100 patients, it was identified that thrombosis can be predicted with high anti-dsDNA and low C3, atherosclerosis (hypertension, hyperlipidemia, and elevated homocysteine), and antiphospholipid antibodies (lupus anticoagulant or anticardiolipin) and could be treated with HCQ. This evidence concerns the gene C3 and deep vein thrombosis.