In order to determine whether SET is involved in the carcinogenesis of colorectal adenocarcinoma and the Wnt signaling pathway, the mRNA expression of SET, protein phosphatase 2 (PP2A) and β-catenin in human colorectal adenocarcinoma and paratumor normal tissues was determined by quantitative real-time polymerase chain reaction (qPCR) analysis. This evidence concerns the gene PTPA and colorectal adenocarcinoma.