In fibrosarcoma (28) and colorectal cancer (29) cells, the mitogen-activated protein kinase (MAPK) signaling pathway inhibited the expression of VEGF, bFGF and STAT3, and the p38 MAPK signaling pathway mediated VEGF expression in bone marrow mesenchymal stem cells (29). The gene discussed is WNK2; the disease is colorectal cancer.