In the present study, an extensive collection of human SC/ASC and AC samples was used to demonstrate that overexpressed PEG10 and TSG101 are associated with large tumor mass size, high TNM stage, lymph node metastasis, invasion and no resection (only biopsy) in SC/ASC and AC, and with poor differentiation in AC. Here, TSG101 is linked to metastatic malignant neoplasm in the lymph nodes.