TSG101 and metastatic malignant neoplasm in the lymph nodes: For AC tumors, the percentage of TSG101- and PEG10-positive expression was significantly higher in the cases with poor differentiation, large tumor mass size, high TNM stage, lymph node metastasis, invasion and collection of tumor samples by biopsy, compared with the well-differentiated cases, small tumor mass, low TNM stage, no lymph node metastasis, no invasion and collection of tumor samples by resection (P<0.05 or P<0.01; Table III).