For instance, in studies of B-cell acute lymphoblastic leukemia, PEG10 mRNA expression was strongly associated with high lipoprotein lipase expression, which is a predictor of unfavorable outcome in B-cell chronic lymphocytic leukemia (10), whereas overexpressed PEG10 increased apoptotic resistance in B cell lineage, acute and chronic lymphocytic leukemia cluster of differentiation (CD)23+/CD5+ B cells (12). This evidence concerns the gene LPL and B-cell chronic lymphocytic leukemia.