The present study demonstrated that AdipoR-1, AdipoR-2 and ObR are expressed in endometrial carcinoma tissue, and that AdipoR-1 expression inversely correlates with high histological grade, deep myometrial invasion, involvement of the lymphovascular space, adnexal invasion and lymph node metastasis, and is associated with improved progression-free and overall survival. The gene discussed is LEPR; the disease is metastatic malignant neoplasm in the lymph nodes.