Subsequently, multivariate Cox regression models using the clinical stage, tumor size, location of neoplasia and BRCA1 methylation revealed that the clinical stage alone provided the independent prognostic factor (OS: P=0.012; RR=7.315; 95% CI, 1.552–34.481; and DFS: P=0.008; RR=5.535; 95% CI, 1.552–19.739) (Table V). Here, BRCA1 is linked to neoplasm.