With regard to the correlations with clinicopathological features, VEGF-C expression was found to correlate well with several factors, including tumor depth, lymphatic invasion, lymph node metastasis and MLVD, while close correlations with VEGFR-3 expression were limited to tumor depth and MLVD. The gene discussed is FLT4; the disease is metastatic malignant neoplasm in the lymph nodes.