There were significant correlations between SUVmax and Glut-1 (r=0.577; P=0.003), HIF-1α (r=1.0; P<0.0001), PI3K (r=1.0; P<0.0001) and p-Akt (r=0.577; P=0.003) expression, indicating that a high FDG uptake was significantly associated with a poor outcome in laryngeal carcinoma. The gene discussed is AKT1; the disease is laryngeal carcinoma.