In the present study, 58.3% (14/24), 50.0% (12/24), 29.2% (7/24) and 54.2% (13/24) of the laryngeal carcinomas were positive for Glut-1, HIF-1α, PI3K and p-Akt protein, respectively (Table I; Fig. 2). Here, AKT1 is linked to laryngeal carcinoma.