Immunohistochemical results for NEC revealed: Chromogranin A (CgA; +) (Fig. 1E), synaptophysin (Syn; +) (Fig. 1F), vimentin (+), thyroid transcription factor-1 (+), CD117 (+) and Ki67 (+ 80%); while those for moderately differentiated adenocarcinoma were as follows: Ki67 (20%), epithelial membrane antigen (EMA; +), CK20 (+), CK7 (+) and villin (+). This evidence concerns the gene MKI67 and neuroendocrine carcinoma.