Furthermore, a statistically significant association between IL-21/rs907715 and SLE was observed in a European-American sample set, where the rs907715 SNP had a minor allele frequency of 35% in the patients as compared with 39% in the controls (χ2=11.55; P=6.8×10−4) (27). This evidence concerns the gene IL21 and systemic lupus erythematosus.