ERBB2 and exocrine pancreatic carcinoma: Although several targeted therapies are available (for example, against EGFR, HER2/neu, HER3, BCR-ABL, PI3 kinase, Akt, MEK, BRAF, CD20, TOR and VEGF), more are needed, particularly for some cancers, such as pancreatic carcinoma, which is still associated with a dismal outcome and for which there are limited therapeutic options.